Human   Beta Cell   Lines

The T-type calcium channel CaV3.2 regulates insulin secretion in the pancreatic β-cell. Barghouth M, Ye Y, Karagiannopoulos A, Ma Y, Cowan E, Wu R, Eliasson L, Renström E, Luan C, Zhang E. Cell Calcium. 2022 Dec 108:102669. PMID: 36347081

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The human batokine EPDR1 regulates β-cell metabolism and function. Cataldo LR, Gao Q, Argemi-Muntadas L, Hodek O, Cowan E, Hladkou S, Gheibi S, Spégel P, Prasad RB, Eliasson L, Scheele C, Fex M, Mulder H, Moritz T. Mol Metab. 2022 Dec 66:101629. PMID: 36343918

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Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding. Alghamdi TA, Krentz NAJ, Smith N, Spigelman AF, Rajesh V, Jha A, Ferdaoussi M, Suzuki K, Yang J, Manning Fox JE, Sun H, Sun Z, Gloyn AL, MacDonald PE. Mol Metab. 2022 Dec 66:101621. PMID: 36307047

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation. Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A. Front Endocrinol (Lausanne). 2022 Nov 28;13:1058345. PMID: 36518246

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Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia. Furth-Lavi J, Hija A, Tornovsky-Babeay S, Mazouz A, Dahan T, Stolovich-Rain M, Klochendler A, Dor Y, Avrahami D, Glaser B. Cell Rep. 2022 Nov 41(9):111719. PMID: 36450253

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies. Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL. iScience. 2022 Oct 25(11):105376. PMID: 36345338

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Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells. Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F. Noncoding RNA. 2022 Oct 8(5):69. PMID: 36287121

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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Beucher A, Miguel-Escalada I, Balboa D, De Vas MG, Maestro MA, Garcia-Hurtado J, Bernal A, Gonzalez-Franco R, Vargiu P, Heyn H, Ravassard P, Ortega S, Ferrer J. Nat Cell Biol. 2022 Oct 24(10):1528-1540. PMID: 36202974

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Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells. Khoubza L, Gilbert N, Kim EJ, Chatelain FC, Feliciangeli S, Abelanet S, Kang D, Lesage F, Bichet D. J Biol Chem. 2022 Oct 298(10):102447. PMID: 36063992

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Glucocorticoids and glucolipotoxicity alter the DNA methylome and function of human EndoC-βH1 cells. Dos Santos C, Karagiannopoulos A, Rafacho A, Perfilyev A, Eliasson L, Ling C, Bacos K. Life Sci. 2022 Oct 307:120854. PMID: 35917939

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ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis. Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A. Front Endocrinol (Lausanne). 2022 Sep 13:991632. PMID: 36171907

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Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells. Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL. Sci Adv. 2022 Sep 16;8(37):eabn5732. PMID: 36103539

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The highly expressed calcium-insensitive synaptotagmin-11 and synaptotagmin-13 modulate insulin secretion. Ofori JK, Karagiannopoulos A, Barghouth M, Nagao M, Andersson ME, Salunkhe VA, Zhang E, Wendt A, Eliasson L. Acta Physiol (Oxf). 2022 Sep 236(1):e13857. PMID: 35753051

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The Transcription Factor YY1 Is Essential for Normal DNA Repair and Cell Cycle in Human and Mouse β-Cells. Martins Peçanha FL, Jaafar R, Werneck-de-Castro JP, Apostolopolou CC, Bhushan A, Bernal-Mizrachi E. Diabetes. 2022 Aug 71(8):1694-1705. PMID: 35594378

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Treating iPSC-Derived β Cells with an Anti-CD30 Antibody-Drug Conjugate Eliminates the Risk of Teratoma Development upon Transplantation. Pellegrini S, Zamarian V, Landi E, Cospito A, Lombardo MT, Manenti F, Citro A, Schiavo Lena M, Piemonti L, Sordi V. Int J Mol Sci. 2022 Aug 23(17):9699. PMID: 36077097

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In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo. Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M. Front Cell Dev Biol. 2022 Aug 10:967765. PMID: 36060810

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Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits. Lasconi C, Pahl MC, Pippin JA, Su C, Johnson ME, Chesi A, Boehm K, Manduchi E, Ou K, Golson ML, Wells AD, Kaestner KH, Grant SFA. Sleep. 2022 Aug 45(8):zsac109. PMID: 35537191

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Islet Gene View-a tool to facilitate islet research. Asplund O, Storm P, Chandra V, Hatem G, Ottosson-Laakso E, Mansour-Aly D, Krus U, Ibrahim H, Ahlqvist E, Tuomi T, Renström E, Korsgren O, Wierup N, Ibberson M, Solimena M, Marchetti P, Wollheim C, Artner I, Mulder H, Hansson O, Otonkoski T, Groop L, Prasad RB. Life Sci Alliance. 2022 Aug 5(12):e202201376. PMID: 35948367

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Macrophages and neutrophils are necessary for ER stress-induced β cell loss. Yang B, Yang L, Wang Y, Maddison LA, Tang Z, Haigh S, Gong Y, Zhang Y, Covington BA, Bosma KJ, Tong X, Page-McCaw P, Gannon M, Deng Q, Chen W. Cell Rep. 2022 Aug 40(8):111255. PMID: 36001973

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Glucose controls co-translation of structurally related mRNAs via the mTOR and eIF2 pathways in human pancreatic beta cells. Bulfoni M, Bouyioukos C, Zakaria A, Nigon F, Rapone R, Del Maestro L, Ait-Si-Ali S, Scharfmann R, Cosson B. Front Endocrinol (Lausanne). 2022 Aug 13:949097. PMID: 35992129

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DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes. Brawerman G, Pipella J, Thompson PJ. Mol Metab. 2022 62:101524. PMID: 35660116

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Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits. Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R. J Biol Chem. 2022 Jul 298(7):102096. PMID: 35660019

Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function. Cheung R, Pizza G, Chabosseau P, Rolando D, Tomas A, Burgoyne T, Wu Z, Salowka A, Thapa A, Macklin A, Cao Y, Nguyen-Tu MS, Dickerson MT, Jacobson DA, Marchetti P, Shapiro J, Piemonti L, de Koning E, Leclerc I, Bouzakri K, Sakamoto K, Smith DM, Rutter GA, Martinez-Sanchez A. Diabetes. 2022 Jul 71(7):1525-1545. PMID: 35476777

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Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation. Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F. Cell Death Discov. 2022 Jul 8(1):340. PMID: 35906204

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Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets. Golec E, Ekström A, Noga M, Omar-Hmeadi M, Lund PE, Villoutreix BO, Krus U, Wozniak K, Korsgren O, Renström E, Barg S, King BC, Blom AM. Proc Natl Acad Sci U S A. 2022 Jul 119(24):e2120083119. PMID: 35666870

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Mitchell-Riley Syndrome: Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations. Passone CGB, Vermillac G, Staels W, Besancon A, Kariyawasam D, Godot C, Lambe C, Talbotec C, Girard M, Chardot C, Berteloot L, Hachem T, Lapillonne A, Poidvin A, Storey C, Neve M, Stan C, Dugelay E, Fauret-Amsellem AL, Capri Y, Cavé H, Ybarra M, Chandra V, Scharfmann R, Bismuth E, Polak M, Carel JC, Pigneur B, Beltrand J. Front Endocrinol (Lausanne). 2022 Jun 22;13:802351. PMID: 35813646

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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Mahajan A…. Morris AP Nat Genet 2022 May 54(5):560-572 PMID: 35551307

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In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model. Dos Santos RS, Medina-Gali RM, Babiloni-Chust I, Marroqui L, Nadal A. Int J Mol Sci. 2022 May 23(9):5040. PMID: 35563431

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Temporal regulation of interferon signalling in human EndoC-βH1 cells. Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG. J Mol Endocrinol. 2022 May 69(2):299-313. PMID: 35521765

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Quantification of Unmethylated Insulin DNA Using Methylation Sensitive Restriction Enzyme Digital Polymerase Chain Reaction. van de Leemkolk FEM, Nell RJ, Versluis M, de Koning EJP, Huurman VAL, Alwayn IPJ, Ploeg RJ, van der Velden PA, Engelse MA. Transpl Int. 2022 Apr 7;35:10167. PMID: 35462792

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Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion. Verma G, Bowen A, Gheibi S, Hamilton A, Muthukumar S, Cataldo LR, Asplund O, Esguerra J, Karagiannopoulos A, Lyons C, Cowan E, Bellodi C, Prasad R, Fex M, Mulder H. J Biol Chem. 2022 Mar;298(3):101692. PMID: 35148993

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Regenerating islet-derived protein 3 gamma (Reg3g) ameliorates tacrolimus-induced pancreatic β-cell dysfunction in mice by restoring mitochondrial function. Li S, Zhou H, Xie M, Zhang Z, Gou J, Yang J, Tian C, Ma K, Wang CY, Lu Y, Li Q, Peng W, Xiang M. Br J Pharmacol. 2022 Jun 179(12):3078-3095. PMID: 35060126

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Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase. Nguyen-Tu MS, Harris J, Martinez-Sanchez A, Chabosseau P, Hu M, Georgiadou E, Pollard A, Otero P, Lopez-Noriega L, Leclerc I, Sakamoto K, Schmoll D, Smith DM, Carling D, Rutter GA. Diabetologia. 2022 Jun 65:997-1011. PMID: 35294578

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G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells. Babiloni-Chust I, Dos Santos RS, Medina-Gali RM, Perez-Serna AA, Encinar JA, Martinez-Pinna J, Gustafsson JA, Marroqui L, Nadal A. Environ Int. 2022 Jun 107250. PMID: 35461094

DOC2b Enhances β-Cell Function via a Novel Tyrosine Phosphorylation-Dependent Mechanism. Chatterjee Bhowmick D, Aslamy A, Bhattacharya S, Oh E, Ahn M, Thurmond DC. Diabetes. 2022 Jun 71(6):1246-1260. PMID: 35377441

Characterization of the Secretome, Transcriptome, and Proteome of Human β Cell Line EndoC-βH1. Ryaboshapkina M, Saitoski K, Hamza GM, Jarnuczak AF, Pechberty S, Berthault C, Sengupta K, Underwood CR, Andersson S, Scharfmann R. Mol Cell Proteomics. 2022 May 21(5):100229. PMID: 35378291

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Loss of Human Beta Cell Identity in a Reconstructed Omental Stromal Cell Environment. Secco B, Saitoski K, Drareni K, Soprani A, Pechberty S, Rachdi L, Venteclef N, Scharfmann R. Cells. 2022 Mar 11(6):924. PMID: 35326375

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High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets. MacMillan HJ, Kong Y, Calvo-Roitberg E, Alonso LC, Pai AA. Sci Rep. 2022 May 12(1):7745. PMID: 35546161

NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes. Xiao P, Takiishi T, Violato NM, Licata G, Dotta F, Sebastiani G, Marselli L, Singh SP, Sze M, Van Loo G, Dejardin E, Gurzov EN, Cardozo AK. Cell Death Dis. 2022 May 13(5):476. PMID: 35589698

Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells. Dettmer R, Niwolik I, Cirksena K, Yoshimoto T, Tang Y, Mehmeti I, Gurgul-Convey E, Naujok O. Diabetologia. 2022 May 65(5):829-843. PMID: 35122482

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Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells. Thomas P, Arden C, Corcoran J, Hacker C, Welters HJ, Morgan NG. Nutr Diabetes. 2022 Apr 12(1):22. PMID: 35443738

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes. Elvira B, Vandenbempt V, Bauzá-Martinez J, Crutzen R, Negueruela J, Ibrahim H, Winder ML, Brahma MK, Vekeriotaite B, Martens PJ, Singh SP, Rossello F, Lybaert P, Otonkoski T, Gysemans C, Wu W, Gurzov EN. Diabetes. 2022 Apr 71(4):653-668. PMID: 35044456

Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic β-Cells: Evaluation of Murine and Human In Vitro Models. Al-Abdulla R, Ferrero H, Soriano S, Boronat-Belda T, Alonso-Magdalena P. Int J Mol Sci. 2022 Apr 23(8):4182. PMID: 35457000

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The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions. Brown MR, Laouteouet D, Delobel M, Villard O, Broca C, Bertrand G, Wojtusciszyn A, Dalle S, Ravier MA, Matveyenko AV, Costes S. Cell Death Dis. 2022 Apr 13(4):353. PMID: 35428762

Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway. Hu Q, Mu J, Liu Y, Yang Y, Liu Y, Pan Y, Zhang Y, Li L, Liu D, Chen J, Zhang F, Jin L. Diabetes. 2022 Mar 71(3):394-411. PMID: 35029277

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death. Karsai M, Zuellig RA, Lehmann R, Cuozzo F, Nasteska D, Luca E, Hantel C, Hodson DJ, Spinas GA, Rutter GA, Gerber PA. J Endocrinol. 2022 Feb 253(1):1-11. PMID: 35017316

Abnormal exocrine-endocrine cell cross-talk promotes β-cell dysfunction and loss in MODY8. Kahraman S, Dirice E, Basile G, Diegisser D, Alam J, Johansson BB, Gupta MK, Hu J, Huang L, Soh CL, Huangfu D, Muthuswamy SK, Raeder H, Molven A, Kulkarni RN. Nat Metab. 2022 Jan 4(1):76-89. PMID: 35058633

MAFA and MAFB regulate exocytosis-related genes in human β-cells. Cataldo LR, Singh T, Achanta K, Bsharat S, Prasad RB, Luan C, Renström E, Eliasson L, Artner I. Acta Physiol (Oxf). 2022 Feb 234(2):e13761. PMID: 34978761

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Human Islet MicroRNA-200c Is Elevated in Type 2 Diabetes and Targets the Transcription Factor ETV5 to Reduce Insulin Secretion. Ofori JK, Karagiannopoulos A, Nagao M, Westholm E, Ramadan S, Wendt A, Esguerra JLS, Eliasson L. Diabetes. 2022 Feb 71(2):275-284. PMID: 34753799

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Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells. Noordstra I, van den Berg CM, Boot FWJ, Katrukha EA, Yu KL, Tas RP, Portegies S, Viergever BJ, de Graaff E, Hoogenraad CC, de Koning EJP, Carlotti F, Kapitein LC, Akhmanova A. J Cell Sci. 2022 Feb 135(3):jcs259430. PMID: 35006275

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Large-Scale Functional Genomics Screen to Identify Modulators of Human β-Cell Insulin Secretion. Szczerbinska I, Tessitore A, Hansson LK, Agrawal A, Ragel Lopez A, Helenius M, Malinowski AR, Gilboa B, Ruby MA, Gupta R, Ämmälä C. Biomedicines. 2022 Jan 10(1):103. PMID: 35052782

2021

Loss of KDM1A in GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing's syndrome: a multicentre, retrospective, cohort study. Chasseloup F, Bourdeau I, Tabarin A, Regazzo D, Dumontet C, Ladurelle N, Tosca L, Amazit L, Proust A, Scharfmann R, Mignot T, Fiore F, Tsagarakis S, Vassiliadi D, Maiter D, Young J, Lecoq AL, Deméocq V, Salenave S, Lefebvre H, Cloix L, Emy P, Dessailloud R, Vezzosi D, Scaroni C, Barbot M, de Herder W, Pattou F, Tétreault M, Corbeil G, Dupeux M, Lambert B, Tachdjian G, Guiochon-Mantel A, Beau I, Chanson P, Viengchareun S, Lacroix A, Bouligand J, Kamenický P. Lancet Diabetes Endocrinol. 2021 Dec 9(12):813-824. PMID: 34655521

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Plasma triacylglycerols are biomarkers of β-cell function in mice and humans. Sánchez-Archidona AR, Cruciani-Guglielmacci C, Roujeau C, Wigger L, Lallement J, Denom J, Barovic M, Kassis N, Mehl F, Weitz J, Distler M, Klose C, Simons K, Ibberson M, Solimena M, Magnan C, Thorens B. Mol Metab. 2021 Dec 54:101355. PMID: 34634522

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Single-Cell Transcriptomics Links Loss of Human Pancreatic β-Cell Identity to ER Stress. Groen N, Leenders F, Mahfouz A, Munoz-Garcia A, Muraro MJ, de Graaf N, Rabelink TJ, Hoeben R, van Oudenaarden A, Zaldumbide A, Reinders MJT, Koning EJP, Carlotti F. Cells. 2021 Dec 10(12):3585. PMID: 34944092

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Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells. Elksnis A, Cen J, Wikström P, Carlsson PO, Welsh N. Biomedicines. 2021 Dec 9(12):1865. PMID: 34944680

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Expression of CD47 in the pancreatic β-cells of people with recent-onset type 1 diabetes varies according to disease endotype. Leslie KA, Richardson SJ, Russell MA, Morgan NG. Diabet Med. 2021 Dec 38(12):e14724. PMID: 34654058

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Dysregulation of the Pdx1/Ovol2/Zeb2 axis in dedifferentiated β-cells triggers the induction of genes associated with epithelial-mesenchymal transition in diabetes. de Jesus DS, Mak TCS, Wang YF, von Ohlen Y, Bai Y, Kane E, Chabosseau P, Chahrour CM, Distaso W, Salem V, Tomas A, Stoffel M, Rutter GA, Latreille M. Mol Metab. 2021 Nov 53:101248. PMID: 33989778

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Lipid Droplets Protect Human beta-Cells From Lipotoxicity-Induced Stress and Cell Identity Changes. Tong X, Stein R. Diabetes. 2021 Nov 70(11):2595-2607. PMID: 34433630

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Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation. Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD. J Clin Invest. 2021 Nov 1;131(21):e144833. PMID: 34491912

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Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer progression in mice. Erener S, Ellis CE, Ramzy A, Glavas MM, O'Dwyer S, Pereira S, Wang T, Pang J, Bruin JE, Riedel MJ, Baker RK, Webber TD, Lesina M, Blüher M, Algül H, Kopp JL, Herzig S, Kieffer TJ. Cell Rep Med. 2021 Nov 2(11):100434. PMID: 34841287

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Oxidative Stress Leads to β-Cell Dysfunction Through Loss of β-Cell Identity. Leenders F, Groen N, de Graaf N, Engelse MA, Rabelink TJ, de Koning EJP, Carlotti F. Front Immunol. 2021 Nov 12:690379. PMID: 34804002

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Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males. Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R. Cell Rep. 2021 Oct 37(2):109813. PMID: 34644565

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Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity. Tang Y, Plötz T, Gräler MH, Gurgul-Convey E. Int J Mol Sci. 2021 Oct ;22(19):10893. PMID: 34639233

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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK. Elksnis A, Schiffer TA, Palm F, Wang Y, Cen J, Turpaev K, Ngamjariyawat A, Younis S, Huang S, Shen Y, Leng Y, Bergsten P, Karlsborn T, Welsh N, Wang X. Clin Sci (Lond). 2021 Oct 135(19):2243-2263. PMID: 34569605

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ZBED6 counteracts high-fat diet-induced glucose intolerance by maintaining beta cell area and reducing excess mitochondrial activation. Wang X, Younis S, Cen J, Wang Y, Krizhanovskii C, Andersson L, Welsh N. Diabetologia. 2021 Oct 64(10):2292-2305. PMID: 34296320

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Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape. Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A. Diabetes. 2021 Oct 70(10):2299-2312. PMID: 34554924

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Butyrate Protects Pancreatic Beta Cells from Cytokine-Induced Dysfunction. Prause M, Pedersen SS, Tsonkova V, Qiao M, Billestrup N. Int J Mol Sci. 2021 Sep 22(19):10427. PMID: 34638768

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STAT3 Regulates Mitochondrial Gene Expression in Pancreatic β-Cells and Its Deficiency Induces Glucose Intolerance in Obesity. Schaschkow A, Pang L, Vandenbempt V, Elvira B, Litwak SA, Vekeriotaite B, Maillard E, Vermeersch M, Paula FMM, Pinget M, Perez-Morga D, Gough DJ, Gurzov EN. Diabetes. 2021 Sep 70(9):2026-2041. PMID: 34183374

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Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion. Vishnu N, Hamilton A, Bagge A, Wernersson A, Cowan E, Barnard H, Sancak Y, Kamer KJ, Spégel P, Fex M, Tengholm A, Mootha VK, Nicholls DG, Mulder H. Mol Metab. 2021 Sep 101239. PMID: 33932586

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Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion. Zakaria A, Berthault C, Cosson B, Jung V, Guerrera IC, Rachdi L, Scharfmann R. J Biol Chem. 2021 Jul 297(1):100839. PMID: 34051232

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SARS-CoV-2 infection induces beta cell transdifferentiation. Tang X, Uhl S, Zhang T, Xue D, Li B, Vandana JJ, Acklin JA, Bonnycastle LL, Narisu N, Erdos MR, Bram Y, Chandar V, Chong ACN, Lacko LA, Min Z, Lim JK, Borczuk AC, Xiang J, Naji A, Collins FS, Evans T, Liu C, tenOever BR, Schwartz RE, Chen S. Cell Metab. 2021 Aug 33(8):1577-1591.e7. PMID: 34081913

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Metformin Perturbs Pancreatic Differentiation From Human Embryonic Stem Cells. Nguyen L, Lim LY, Ding SSL, Amirruddin NS, Hoon S, Chan SY, Teo AKK. Diabetes. 2021 Aug 70(8):1689-1702. PMID: 33958328

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Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection. Chaffey JR, Young J, Leslie KA, Partridge K, Akhbari P, Dhayal S, Hill JL, Wedgwood KCA, Burnett E, Russell MA, Richardson SJ, Morgan NG. Sci Rep. 2021 Aug 11(1):15624. PMID: 34341375

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The Ca2+ -binding protein sorcin stimulates transcriptional activity of the unfolded protein response mediator ATF6. Parks SZ, Gao T, Jimenez Awuapura N, Ayathamattam J, Chabosseau PL, Kalvakolanu DV, Valdivia HH, Rutter GA, Leclerc I. FEBS Lett 2021 Jul 595(13):1782-1796. PMID: 33960419

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Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects. Jian X, Felsenfeld G. Nat Commun. 2021 Jul 15;12(1):4338. PMID: 34267199

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A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis. Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL. Islets. 2021 Jul 4;13(3-4):51-65. PMID: 34241569

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Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD. Jeffery N, Chambers D, Invergo BM, Ames RM, Harries LW. Cell Biosci. Cell Biosci. 2021 Jul 11(1):144. PMID: 34301309

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RNA m6A reader IMP2/IGF2BP2 promotes pancreatic β-cell proliferation and insulin secretion by enhancing PDX1 expression. Regué L, Zhao L, Ji F, Wang H, Avruch J, Dai N. Mol Metab. 2021 Jun 48:101209. PMID: 33705986

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Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis. So WY, Liu WN, Teo AKK, Rutter GA, Han W. Sci Transl Med. 2021 Jun 13(600):eabb1038. PMID: 34193609

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Effects of proprotein convertase subtilisin kexin type 9 modulation in human pancreatic beta cells function. Ramin-Mangata S, Thedrez A, Nativel B, Diotel N, Blanchard V, Wargny M, Aguesse A, Billon-Crossouard S, Vindis C, Le May C, Hulin P, Armanet M, Gmyr V, Pattou F, Croyal M, Meilhac O, Nobécourt E, Cariou B, Lambert G. Atherosclerosis. 2021 Jun 326:47-55. PMID: 33933263

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In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. Charbord J, Ren L, Sharma RB, Johansson A, Ågren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O. Nat Metab. 2021 May 3(5):682-700. PMID: 34031592

Decreased GLUT2 and glucose uptake contribute to insulin secretion defects in MODY3/HNF1A hiPSC-derived mutant beta cells. Low BSJ, Lim CS, Ding SSL, Tan YS, Ng NHJ, Krishnan VG, Ang SF, Neo CWY, Verma CS, Hoon S, Lim SC, Tai ES, Teo AKK. Nat Commun. 2021 May 12(1):3133. PMID: 34035238

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The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation. Zhou AX, Mondal T, Tabish AM, Abadpour S, Ericson E, Smith DM, Knöll R, Scholz H, Kanduri C, Tyrberg B, Althage M. Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E846-E857. PMID: 33682459

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Syntaxin 4 Mediates NF-kappaB Signaling and Chemokine Ligand Expression via Specific Interaction With IkappaBbeta. Veluthakal R, Oh E, Ahn M, Chatterjee Bhowmick D, Thurmond DC. Diabetes. 2021 Apr 70(4):889-902. PMID: 33526588

IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion. Lin H, Yan Y, Luo Y, So WY, Wei X, Zhang X, Yang X, Zhang J, Su Y, Yang X, Zhang B, Zhang K, Jiang N, Chow BKC, Han W, Wang F, Rao F. Nat Commun. 2021 Apr 12(1):2461. PMID: 33911083

Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene. Akerman I, Maestro MA, De Franco E, Grau V, Flanagan S, García-Hurtado J, Mittler G, Ravassard P, Piemonti L, Ellard S, Hattersley AT, Ferrer J. Cell Rep. 2021 Apr 35(2):108981. PMID: 33852861

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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis. Mousavy Gharavy SN, Owen BM, Millership SJ, Chabosseau P, Pizza G, Martinez-Sanchez A, Tasoez E, Georgiadou E, Hu M, Fine NHF, Jacobson DA, Dickerson MT, Idevall-Hagren O, Montoya A, Kramer H, Mehta Z, Withers DJ, Ninov N, Gadue PJ, Cardenas-Diaz FL, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Leclerc I, Voz M, Rutter GA. Diabetologia. 2021 Apr 64(4):850-864. PMID: 33492421

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells. Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL. Auto Immun Highlights. 2021 Mar 12(1):6. PMID: 33773604

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Adipocyte-derived extracellular vesicles regulate survival and function of pancreatic β cells. Gesmundo I, Pardini B, Gargantini E, Gamba G, Birolo G, Fanciulli A, Banfi D, Congiusta N, Favaro E, Deregibus MC, Togliatto G, Zocaro G, Brizzi MF, Luque RM, Castaño JP, Bocchiotti MA, Arolfo S, Bruno S, Nano R, Morino M, Piemonti L, Ong H, Matullo G, Falcón-Pérez JM, Ghigo E, Camussi G, Granata R. JCI Insight. 2021 Mar 6(5):e141962. PMID: 33539327

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion. Hu M, Cebola I, Carrat G, Jiang S, Nawaz S, Khamis A, Canouil M, Froguel P, Schulte A, Solimena M, Ibberson M, Marchetti P, Cardenas-Diaz FL, Gadue PJ, Hastoy B, Almeida-Souza L, McMahon H, Rutter GA. Cell Rep. 2021 Mar 34(11):108881. PMID: 33730570

Inceptor counteracts insulin signalling in β-cells to control glycaemia. Ansarullah, Jain C, Far FF, Homberg S, Wißmiller K, von Hahn FG, Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J, Oppenländer L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M, Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R, Plettenburg O, Müller TD, Meier M, Tschöp MH, Coskun Ü, Lickert H. Nature. 2021 Feb 590(7845):326-331. PMID: 33505018

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SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. Nat Metab. 2021 Feb;3(2):149-165. PMID: 33536639

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A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chain proteins to prevent β-cell apoptosis. Ahn M, Oh E, McCown EM, Wang X, Veluthakal R, Thurmond DC. Metabolism. 2021 Feb 115:154431. PMID: 33181191

miR-375- and miR-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity But Strong Antitumor Efficiency in Colorectal Carcinomas. Hazini A, Dieringer B, Pryshliak M, Knoch KP, Heimann L, Tolksdorf B, Pappritz K, El-Shafeey M, Solimena M, Beling A, Kurreck J, Klingel K, Fechner H. Hum Gene Ther. 2021 Feb 32(3-4):216-230. PMID: 33481658

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Regulation of ATR-dependent DNA damage response by nitric oxide. Yeo CT, Stancill JS, Oleson BJ, Schnuck JK, Stafford JD, Naatz A, Hansen PA, Corbett JA. J Biol Chem. 2021 Jan 296:100388. PMID: 33567339

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Long-chain saturated fatty acid species are not toxic to human pancreatic beta-cells and may offer protection against pro-inflammatory cytokine induced beta-cell death. Thomas P, Leslie KA, Welters HJ, Morgan NG. Nutr Metab (Lond). 2021 Jan 12;18(1):9. PMID: 33435998

Harnessing reaction-based probes to preferentially target pancreatic β-cells and β-like cells. Kahraman S, Manna D, Dirice E, Maji B, Small J, Wagner BK, Choudhary A, Kulkarni RN. Life Sci Alliance. 2021 Jan; 4(4):e202000840. PMID: 33514654

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